A comparative evaluation of anti-tumor activity following oral and intravenous delivery of doxorubicin in a xenograft model of breast tumor

Abstract Purpose Natural materials have been extensively studied for oral drug delivery due to their biodegradability and other unique properties. In the current research, we fabricated sodium caseinate nanomicelles (NaCNs) using casein as a natural polymer develop controlled-release system that would improve therapeutic potential of doxorubicin (DOX) reduce its toxicity. Methods DOX-loaded NaCNs were synthesized thoroughly characterized, then subjected in vivo anti-tumor evaluation bio-distribution analysis 4T1-induced breast cancer model. Results Our findings indicated tumor shrink by eight-fold group orally treated with DOX-NaCNs when compared free DOX. The accumulated 1.27-fold more from administered intravenously DOX-NaCNs, 6.8-fold DOX, 8.34-times comparison, lead significant reduction size (5.66 ± 4.36 mm 3 ) (10.29 4.86 on day 17 experiment. well tolerated at single dose 2000 mg/kg an acute toxicity study. Conclusion enhanced effects might be related controlled release DOX intravenous formulation DOX-NaCNs. Moreover, is recognized safe non-toxic excellent profile high has chemotherapy.